Radboud University Nijmegen
P.O. Box 9102
6500 HC Nijmegen
The Netherlands
P.O. Box 9102
6500 HC Nijmegen
The Netherlands
PhD Student for Molecular Carcinogenesis
Maximum Salary: € 2,612 gross/month
Closing date: 14 January 2011
Job description
Recurring chromosomal abnormalities have been identified in a variety of cancers, but are most frequently associated with haematological malignancies such as acute myeloid leukemia (AML).
These cytogenetic changes often cause gene fusions leading to expression of chimeric oncofusion proteins. In this project you will focus on unravelling the role of these oncofusion proteins in carcinogenesis.
Your aim will be to identify the binding regions, the transcriptional consequences and epigenetic features associated with oncofusion protein expression.
You will use next-generation sequencing to identify oncofusion protein target sites, which then will be further characterized, structurally as well as functionally, in relation to the aetiology of acute myeloid leukemia.
Requirements
You should have:
• an MSc degree in Biomedical Sciences/Biology/Molecular Life Sciences/Bioinformatics;
• experience in Molecular and Cell Biology and/or Bioinformatics;
• a strong affinity for fundamental research related to human disease;
• a well-structured working style;
• well-developed social and communication skills.
You are accurate, and motivated to perform cutting-edge research.
Organization
Research at the department of Molecular Biology is aimed at unravelling the molecular basis of development and differentiation emanating from the genome and epigenome in the context of health and disease with an emphasis on cancer.
State-of-the-art technologies are applied ranging from single molecule studies to genome-wide elucidation of genetic and epigenetic pathways and mechanisms.
A next-generation sequencing platform is operational in the department for analysis of transcription factor binding sites, epigenetic marks, DNA methylation and RNA seq at a comprehensive genome-wide scale.
In-depth analysis of genome-wide data is performed and sustained by our own bioinformatic team as well as with outside collaborators.
Moreover, the group participates in a number of international consortia tackling pathways and molecular mechanisms in lineage commitment of (embryonic) stem cells.
Website: http://www.ncmls.nl/molbio/home.htm
Application
You can apply for the job (mention the vacancy number 62.92.10) before 14 January 2011 by sending your application -preferably by email- to:
RU Nijmegen, FNWI, P&O, mr. M. Frieling
P.O. Box 9010, 6500 GL Nijmegen, NL
Telephone: +31 24 3652294
E-mail: pz@science.ru.nl
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