InStem SCIENTIST/RA/LABORATORY MANAGER Openings in HIGH THROUGHPUT SCREENING ~ helpBIOTECH
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04 September 2013

InStem SCIENTIST/RA/LABORATORY MANAGER Openings in HIGH THROUGHPUT SCREENING

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Institute for Stem Cell Biology and Regenerative Medicine, Bangalore

(www.instem.res.in), an autonomous research Institute under the Department of Biotechnology, Government of India invites applications from suitable individuals for the following contractual positions for a project at  “Centre for Chemical Biology and Therapeutics”  funded by the Government of India.

1. SENIOR SCIENTIST – HIGH THROUGHPUT SCREENING AUTOMATION

KNOWLEDGE, EXPERIENCE AND SKILLS

  • PhD, in Molecular Biology/Cell Biology/Biochemistry

  • 3-5 yrs of industry experience beyond PhD in assay design, execution, and high-throughput screening

  • Previous experience using liquid handling stations, implementing high content screens, automated microscopy and handling large data sets are encouraged to apply

  • Experience in areas such as chromatin regulation, cell cycle and cell signaling is desirable

JOB DESCRIPTION

  • In this position you will support chemical biology efforts underpinning new lead discovery by providing high throughput biology expertise including, but not limited to the following;

  • Develop, optimize and validate biological assays amenable to automation and high throughput screening

  • Automate high throughput screening assays to support lead discovery programs.

  • Perform primary high throughput screening, secondary hit profiling assays, and focused small molecule screens

  • Program and operate custom-integrated automation systems, prepare assay reagents and execute assays

  • Perform data analysis, reporting and integration with database software

  • Interact with multidisciplinary project teams for lead discovery

  • Participate in project team meeting and contribute to the projects intellectually and communicate data

DUTIES AND JOB FUNCTIONS

  • Specific experience with high throughput screening and assay development Experience in biochemical and cell based assays applying luminescence, fluorescence, TR-FRET, FP, alpha screen, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies.
  • Solid understanding of modern high throughput screening assay technologies
  • Specific experience using laboratory automation equipment

  • Excellent computer skills with experience in data analysis

  • Must be detail oriented, well organized, and have strong communication skills

  • Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment

  • Managerial experience of junior scientists

2. HIGH THROUGHPUT SCREENING TECHNOLOGY ASSOCIATE

KNOWLEDGE, EXPERIENCE AND SKILLS

  • Master's degree in discipline of life sciences B.Tech in Bio-Technology with 1-3 years of work experience

  • Substantial experience with high throughput screening of enzyme/cell-based assay using small molecule libraries is essential.

JOB DESCRIPTION

  • Support chemical biology efforts underpinning new lead discovery efforts by providing high throughput biology expertise including, but not limited to the following;

  • Proficient in biochemistry, enzymology, assay development, lab automation and HTS

  • High throughput screening assays and application of various in vitro techniques

  • Specific experience with biochemical and cell based assays applying luminescence, fluorescence, TR-FRET, FP and alpha screen assays

  • HTS sample processing, data generation, data interpretation and data reporting

  • Responsible for conducting in vitro animal cell culture, etc. as and when required

  • Assist in maintenance of HTS compound/sample libraries, laboratory administrative requirements and maintenance of good laboratory practices in work environment

DUTIES AND JOB FUNCTIONS

  • Understanding of modern high throughput screening assay technologies

  • Experience in using laboratory automation equipment

  • Computer skills with experience in data analysis

  • Must be detail oriented, well organized, and have strong communication skills

  • Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment

3.LABORATORY MANAGER

KNOWLEDGE, EXPERIENCE AND SKILLS

  • Bachelor/Masters /Degree in Molecular Biology/Cell Biology/Biochemistry

  • 3-5 yrs of laboratory experience in industry/research organization

  • Excellent interpersonal communication skills, multi-tasking, proactive and a flair to ensure functionality of lab equipments

JOB DESCRIPTION:

  • Supervise day-to-day working of the laboratory and maintenance of smooth functioning and good lab practices

  • Being the contact person of the lab for all administrative purposes

  • Keep track of purchase, customs, calibration, annual maintenance contracts and repairs of all lab equipments

  • Ensure proper functioning and care of equipment, and refer to appropriate source for preventive and corrective maintenance

  • Inventory control along with the stores-in-charge. This will include getting quotations from companies/vendors after co-coordinating with sections-in-charge and the purchase department

  • Co-ordinating with the IT team for all laboratory needs

  • Ensure record of all related documentation

  • Understand common experimental protocols of the laboratory including bacterial and cell culture and ability to carry out basic experimental protocols independently

  • Opportunity to actively participate or lead scientific projects

Application procedure:

An application package consisting of the following information should be sent by email to: kk@instem.res.in and by hard copy to the Officer on Special Duty,Institute for Stem Cell Biology and Regenerative Medicine, NCBS-TIFR, GKVK PO, Bellary Road, Bangalore- 560065, so as to reach by  20-09-2013.

  • Up-to-date CV with names and contact details of three referees

  • A one-page description of why you believe you are an appropriate candidate for the role

  • A case study of “a challenging situation I recently found myself in”

General:

  1. Age will not be bar for candidates with exceptional experience in the specific field.

  2. Candidates selected will be offered monthly consolidated salary (Lumpsum) of Rs.1,10,000/- for post 1, Rs.70,000/- for post 2 and Rs. 21,000/- for post 3.

  3. The selected candidate will be initially appointed on probation for a period of one year. Depending on the performance of the selected candidates, the appointment may be renewed annually or till the expiry of the project.

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